De Novo Cytomegalovirus Colitis in a Donor-Seronegative/Recipient-Seronegative Kidney Transplant Recipient

نویسندگان

چکیده

Cytomegalovirus (CMV) is one of the most frequent microbes linked with kidney transplant recipients. CMV infection typically classified as virus isolation in any body fluid or specimen. We present a 43-year-old man who underwent deceased donor donor-seronegative and recipient-seronegative (CMV D-/R-) status completed three months prophylaxis high-dose acyclovir given his low-risk status. He was admitted for complaints profuse watery diarrhea persistent fevers lasting week duration. His infectious workup led to quantitative nucleic acid amplification test (QNAT) polymerase chain reaction (PCR) 239,977 IU/mL biopsy-proven diagnosis invasive colitis. treated inpatient intravenous ganciclovir two weeks then de-escalated oral valganciclovir until achieving viremia resolution undetectable QNAT PCR an outpatient. This case illustrates importance changing epidemiology clinical presentation disease solid organ (SOT) recipients era new immunosuppression regimens improved detection early post-transplant period.

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ژورنال

عنوان ژورنال: Cureus

سال: 2023

ISSN: ['2168-8184']

DOI: https://doi.org/10.7759/cureus.43509